A Game-By-Game Look at the San Francisco 49ers 2025 Schedule Release
he San Francisco 49ers have announced their 2025 regular season schedule along with the opponents and date ranges for the team’s three preseason games.
The 49ers will face the NFC South and AFC South in cross-divisional play, while continuing to battle their NFC West opponents twice a year. San Francisco will also host the Chicago Bears (Week 17) and visit the New York Giants (Week 9) and Cleveland Browns (Week 13). The Niners open the regular season on the road as they visit the Seattle Seahawks.
The team is scheduled to play in five prime time games during the regular season, including three at home, with two on Monday night (Week 12 vs. Carolina & Week 16 at Indianapolis), two on Sunday night (Week 7 vs. Atlanta & Week 17 vs. Chicago) and one on Thursday night (Week 5 at Los Angeles Rams).
A Closer Look at the 2025 Schedule…
- San Francisco will open the regular season on the road (at Seattle) for the fourth time in five seasons and for the first time since visiting the Pittsburgh Steelers in Week 1 of the 2023 season.
- The 49ers open the season on the road against an NFC West opponent for the first time since the 2010 season when they visited Seattle in Week 1.
- The Niners open the season against an NFC West opponent for the first time since the 2020 season when they hosted the Arizona Cardinals in Week 1.
- The Niners will make back-to-back road trips to begin the season for the first time since the 2023 season [Week 1 at Pit. (9/10/23) & Week 2 at LAR (9/17/23)].
- San Francisco will play in at least five prime time games for the fourth-consecutive season.
- The 49ers close the regular season at home (Week 18 vs. Seattle) for the third time in five seasons.
